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KMID : 0811720060100060303
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Korean Journal of Physiology & Pharmacology
2006 Volume.10 No. 6 p.303 ~ p.308
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NMDA Receptor-dependent Inhibition of Synaptic Transmission by Acute Ethanol Treatment in Rat Corticostriatal Slices
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Choi Se-Joon
Kim Ki-Jung
Cho Hyeong-Seok
Kim Seong-Yun
Yim Dong-Seok
Cho Young-Jin
Hahn Sang-June
Sung Ki-Wug
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Abstract
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The effects of ethanol on corticostriatal synaptic transmission were examined, using extracellular recording and analysis of population spike amplitudes in rat brain slices, to study how acute ethanol intoxication impairs striatal function. Ethanol caused a decrease in population spike amplitudes in a dose dependent manner (50∼200 mM). Pretreatment with picrotoxin, a γ-amino butyric acid (GABA)A receptor antagonist, increased the population spikes but ethanol (100 mM) was still effective in decreasing the population spikes under this condition. In the presence of (DL)-2-amino-5-phosphonovaleric acid (APV), N-methyl-D-aspartate (NMDA) receptor antagonist, the inhibitory action of ethanol on population spikes was not shown. These results suggest that ethanol inhibits the glutamatergic corticostriatal synaptic transmission through blockade of NMDA receptors.
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KEYWORD
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Striatum, Ethanol, Extracellular recording, Population spike, Glutamate receptor, Synaptic transmission
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